Epigenetic and Transcriptomic Regulation of Lung Repair during Recovery from Influenza Infection.
Identifieur interne : 000B00 ( Main/Exploration ); précédent : 000A99; suivant : 000B01Epigenetic and Transcriptomic Regulation of Lung Repair during Recovery from Influenza Infection.
Auteurs : Derek A. Pociask [États-Unis] ; Keven M. Robinson [États-Unis] ; Kong Chen [États-Unis] ; Kevin J. Mchugh [États-Unis] ; Michelle E. Clay [États-Unis] ; Grace T. Huang [États-Unis] ; Panayiotis V. Benos [États-Unis] ; Yvonne M W. Janssen-Heininger [États-Unis] ; Jay K. Kolls [États-Unis] ; Vikas Anathy [États-Unis] ; John F. Alcorn [États-Unis]Source :
- The American journal of pathology [ 1525-2191 ] ; 2017.
Descripteurs français
- KwdFr :
- Analyse de profil d'expression de gènes, Animaux, Cicatrisation de plaie (génétique), Facteurs temps, Infections à Orthomyxoviridae (génétique), Infections à Orthomyxoviridae (immunologie), Infections à Orthomyxoviridae (virologie), Inflammation (anatomopathologie), Lymphocytes T (immunologie), Pneumopathie infectieuse (microbiologie), Pneumopathie infectieuse (étiologie), Poumon (métabolisme), Poumon (virologie), Souris de lignée C57BL, Stress du réticulum endoplasmique (génétique), Transcriptome (génétique), microARN (génétique), microARN (métabolisme), Épigenèse génétique, Épithélium (anatomopathologie), Évolution de la maladie.
- MESH :
- anatomopathologie : Inflammation, Épithélium.
- génétique : Cicatrisation de plaie, Infections à Orthomyxoviridae, Stress du réticulum endoplasmique, Transcriptome, microARN.
- immunologie : Infections à Orthomyxoviridae, Lymphocytes T.
- microbiologie : Pneumopathie infectieuse.
- métabolisme : Poumon, microARN.
- virologie : Infections à Orthomyxoviridae, Poumon.
- étiologie : Pneumopathie infectieuse.
- Analyse de profil d'expression de gènes, Animaux, Facteurs temps, Souris de lignée C57BL, Épigenèse génétique, Évolution de la maladie.
English descriptors
- KwdEn :
- Animals, Disease Progression, Endoplasmic Reticulum Stress (genetics), Epigenesis, Genetic, Epithelium (pathology), Gene Expression Profiling, Inflammation (pathology), Lung (metabolism), Lung (virology), Mice, Inbred C57BL, MicroRNAs (genetics), MicroRNAs (metabolism), Orthomyxoviridae Infections (genetics), Orthomyxoviridae Infections (immunology), Orthomyxoviridae Infections (virology), Pneumonia (etiology), Pneumonia (microbiology), T-Lymphocytes (immunology), Time Factors, Transcriptome (genetics), Wound Healing (genetics).
- MESH :
- chemical , genetics : MicroRNAs.
- etiology : Pneumonia.
- genetics : Endoplasmic Reticulum Stress, Orthomyxoviridae Infections, Transcriptome, Wound Healing.
- immunology : Orthomyxoviridae Infections, T-Lymphocytes.
- metabolism : Lung, MicroRNAs.
- microbiology : Pneumonia.
- pathology : Epithelium, Inflammation.
- virology : Lung, Orthomyxoviridae Infections.
- Animals, Disease Progression, Epigenesis, Genetic, Gene Expression Profiling, Mice, Inbred C57BL, Time Factors.
Abstract
Seasonal and pandemic influenza is a cause of morbidity and mortality worldwide. Most people infected with influenza virus display mild-to-moderate disease phenotypes and recover within a few weeks. Influenza is known to cause persistent alveolitis in animal models; however, little is known about the molecular pathways involved in this phenotype. We challenged C57BL/6 mice with influenza A/PR/8/34 and examined lung pathologic processes and inflammation, as well as transcriptomic and epigenetic changes at 21 to 60 days after infection. Influenza induced persistent parenchymal lung inflammation, alveolar epithelial metaplasia, and epithelial endoplasmic reticulum stress that were evident after the clearance of virus and resolution of morbidity. Influenza infection induced robust changes in the lung transcriptome, including a significant impact on inflammatory and extracellular matrix protein expression. Despite the robust changes in lung gene expression, preceding influenza (21 days) did not exacerbate secondary Staphylococcus aureus infection. Finally, we examined the impact of influenza on miRNA expression in the lung and found an increase in miR-155. miR-155 knockout mice recovered from influenza infection faster than controls and had decreased lung inflammation and endoplasmic reticulum stress. These data illuminate the dynamic molecular changes in the lung in the weeks after influenza infection and characterize the repair process, identifying a novel role for miR-155.
DOI: 10.1016/j.ajpath.2016.12.012
PubMed: 28193481
Affiliations:
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Le document en format XML
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Pociask</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pulmonary Critical Care and Environmental Medicine, Tulane University School of Medicine, New Orleans, Louisiana; Richard K. Mellon Foundation Institute, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Pulmonary Critical Care and Environmental Medicine, Tulane University School of Medicine, New Orleans, Louisiana; Richard K. Mellon Foundation Institute, Children's Hospital of Pittsburgh of UPMC, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Robinson, Keven M" sort="Robinson, Keven M" uniqKey="Robinson K" first="Keven M" last="Robinson">Keven M. Robinson</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Chen, Kong" sort="Chen, Kong" uniqKey="Chen K" first="Kong" last="Chen">Kong Chen</name><affiliation wicri:level="2"><nlm:affiliation>Richard K. Mellon Foundation Institute, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Richard K. Mellon Foundation Institute, Children's Hospital of Pittsburgh of UPMC, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Mchugh, Kevin J" sort="Mchugh, Kevin J" uniqKey="Mchugh K" first="Kevin J" last="Mchugh">Kevin J. Mchugh</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pediatrics, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Pediatrics, Children's Hospital of Pittsburgh of UPMC, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Clay, Michelle E" sort="Clay, Michelle E" uniqKey="Clay M" first="Michelle E" last="Clay">Michelle E. Clay</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pediatrics, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Pediatrics, Children's Hospital of Pittsburgh of UPMC, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Huang, Grace T" sort="Huang, Grace T" uniqKey="Huang G" first="Grace T" last="Huang">Grace T. Huang</name><affiliation wicri:level="2"><nlm:affiliation>Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, Pennsylvania; PhD Program in Computational Biology, Carnegie Mellon University and University of Pittsburgh, Pittsburgh, Pennsylvania.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, Pennsylvania; PhD Program in Computational Biology, Carnegie Mellon University and University of Pittsburgh, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Benos, Panayiotis V" sort="Benos, Panayiotis V" uniqKey="Benos P" first="Panayiotis V" last="Benos">Panayiotis V. Benos</name><affiliation wicri:level="2"><nlm:affiliation>Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, Pennsylvania.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Janssen Heininger, Yvonne M W" sort="Janssen Heininger, Yvonne M W" uniqKey="Janssen Heininger Y" first="Yvonne M W" last="Janssen-Heininger">Yvonne M W. Janssen-Heininger</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, University of Vermont, Burlington, Vermont.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Vermont</region></placeName><wicri:cityArea>Department of Pathology, University of Vermont, Burlington</wicri:cityArea></affiliation></author><author><name sortKey="Kolls, Jay K" sort="Kolls, Jay K" uniqKey="Kolls J" first="Jay K" last="Kolls">Jay K. Kolls</name><affiliation wicri:level="2"><nlm:affiliation>Richard K. Mellon Foundation Institute, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Richard K. Mellon Foundation Institute, Children's Hospital of Pittsburgh of UPMC, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Anathy, Vikas" sort="Anathy, Vikas" uniqKey="Anathy V" first="Vikas" last="Anathy">Vikas Anathy</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, University of Vermont, Burlington, Vermont.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Vermont</region></placeName><wicri:cityArea>Department of Pathology, University of Vermont, Burlington</wicri:cityArea></affiliation></author><author><name sortKey="Alcorn, John F" sort="Alcorn, John F" uniqKey="Alcorn J" first="John F" last="Alcorn">John F. Alcorn</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pediatrics, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania. Electronic address: john.alcorn@chp.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Pediatrics, Children's Hospital of Pittsburgh of UPMC, Pittsburgh</wicri:cityArea></affiliation></author></analytic><series><title level="j">The American journal of pathology</title><idno type="eISSN">1525-2191</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Disease Progression</term><term>Endoplasmic Reticulum Stress (genetics)</term><term>Epigenesis, Genetic</term><term>Epithelium (pathology)</term><term>Gene Expression Profiling</term><term>Inflammation (pathology)</term><term>Lung (metabolism)</term><term>Lung (virology)</term><term>Mice, Inbred C57BL</term><term>MicroRNAs (genetics)</term><term>MicroRNAs (metabolism)</term><term>Orthomyxoviridae Infections (genetics)</term><term>Orthomyxoviridae Infections (immunology)</term><term>Orthomyxoviridae Infections (virology)</term><term>Pneumonia (etiology)</term><term>Pneumonia (microbiology)</term><term>T-Lymphocytes (immunology)</term><term>Time Factors</term><term>Transcriptome (genetics)</term><term>Wound Healing (genetics)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Analyse de profil d'expression de gènes</term><term>Animaux</term><term>Cicatrisation de plaie (génétique)</term><term>Facteurs temps</term><term>Infections à Orthomyxoviridae (génétique)</term><term>Infections à Orthomyxoviridae (immunologie)</term><term>Infections à Orthomyxoviridae (virologie)</term><term>Inflammation (anatomopathologie)</term><term>Lymphocytes T (immunologie)</term><term>Pneumopathie infectieuse (microbiologie)</term><term>Pneumopathie infectieuse (étiologie)</term><term>Poumon (métabolisme)</term><term>Poumon (virologie)</term><term>Souris de lignée C57BL</term><term>Stress du réticulum endoplasmique (génétique)</term><term>Transcriptome (génétique)</term><term>microARN (génétique)</term><term>microARN (métabolisme)</term><term>Épigenèse génétique</term><term>Épithélium (anatomopathologie)</term><term>Évolution de la maladie</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>MicroRNAs</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Inflammation</term><term>Épithélium</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Pneumonia</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Endoplasmic Reticulum Stress</term><term>Orthomyxoviridae Infections</term><term>Transcriptome</term><term>Wound Healing</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Cicatrisation de plaie</term><term>Infections à Orthomyxoviridae</term><term>Stress du réticulum endoplasmique</term><term>Transcriptome</term><term>microARN</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Infections à Orthomyxoviridae</term><term>Lymphocytes T</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Orthomyxoviridae Infections</term><term>T-Lymphocytes</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Lung</term><term>MicroRNAs</term></keywords><keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Pneumopathie infectieuse</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Pneumonia</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Poumon</term><term>microARN</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Epithelium</term><term>Inflammation</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à Orthomyxoviridae</term><term>Poumon</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Lung</term><term>Orthomyxoviridae Infections</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Pneumopathie infectieuse</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Progression</term><term>Epigenesis, Genetic</term><term>Gene Expression Profiling</term><term>Mice, Inbred C57BL</term><term>Time Factors</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Analyse de profil d'expression de gènes</term><term>Animaux</term><term>Facteurs temps</term><term>Souris de lignée C57BL</term><term>Épigenèse génétique</term><term>Évolution de la maladie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Seasonal and pandemic influenza is a cause of morbidity and mortality worldwide. Most people infected with influenza virus display mild-to-moderate disease phenotypes and recover within a few weeks. Influenza is known to cause persistent alveolitis in animal models; however, little is known about the molecular pathways involved in this phenotype. We challenged C57BL/6 mice with influenza A/PR/8/34 and examined lung pathologic processes and inflammation, as well as transcriptomic and epigenetic changes at 21 to 60 days after infection. Influenza induced persistent parenchymal lung inflammation, alveolar epithelial metaplasia, and epithelial endoplasmic reticulum stress that were evident after the clearance of virus and resolution of morbidity. Influenza infection induced robust changes in the lung transcriptome, including a significant impact on inflammatory and extracellular matrix protein expression. Despite the robust changes in lung gene expression, preceding influenza (21 days) did not exacerbate secondary Staphylococcus aureus infection. Finally, we examined the impact of influenza on miRNA expression in the lung and found an increase in miR-155. miR-155 knockout mice recovered from influenza infection faster than controls and had decreased lung inflammation and endoplasmic reticulum stress. These data illuminate the dynamic molecular changes in the lung in the weeks after influenza infection and characterize the repair process, identifying a novel role for miR-155.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Pennsylvanie</li><li>Vermont</li></region></list><tree><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Pociask, Derek A" sort="Pociask, Derek A" uniqKey="Pociask D" first="Derek A" last="Pociask">Derek A. Pociask</name></region><name sortKey="Alcorn, John F" sort="Alcorn, John F" uniqKey="Alcorn J" first="John F" last="Alcorn">John F. Alcorn</name><name sortKey="Anathy, Vikas" sort="Anathy, Vikas" uniqKey="Anathy V" first="Vikas" last="Anathy">Vikas Anathy</name><name sortKey="Benos, Panayiotis V" sort="Benos, Panayiotis V" uniqKey="Benos P" first="Panayiotis V" last="Benos">Panayiotis V. Benos</name><name sortKey="Chen, Kong" sort="Chen, Kong" uniqKey="Chen K" first="Kong" last="Chen">Kong Chen</name><name sortKey="Clay, Michelle E" sort="Clay, Michelle E" uniqKey="Clay M" first="Michelle E" last="Clay">Michelle E. Clay</name><name sortKey="Huang, Grace T" sort="Huang, Grace T" uniqKey="Huang G" first="Grace T" last="Huang">Grace T. Huang</name><name sortKey="Janssen Heininger, Yvonne M W" sort="Janssen Heininger, Yvonne M W" uniqKey="Janssen Heininger Y" first="Yvonne M W" last="Janssen-Heininger">Yvonne M W. Janssen-Heininger</name><name sortKey="Kolls, Jay K" sort="Kolls, Jay K" uniqKey="Kolls J" first="Jay K" last="Kolls">Jay K. Kolls</name><name sortKey="Mchugh, Kevin J" sort="Mchugh, Kevin J" uniqKey="Mchugh K" first="Kevin J" last="Mchugh">Kevin J. Mchugh</name><name sortKey="Robinson, Keven M" sort="Robinson, Keven M" uniqKey="Robinson K" first="Keven M" last="Robinson">Keven M. Robinson</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:28193481" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a StressCovidV1
| This area was generated with Dilib version V0.6.33. |  |